TABLE 6

Rank order of agonist activity based upon RAi values calculated via the operational method Data were taken from Tables 1, 4, and 5 and Fig. 7.


Receptor

RAi Rank Order
M1 Oxo-M > >arecoline = carbachol > S-aceclidine = McN-A-343 > pilocarpine > R-aceclidine
M2 Oxo-M > carbachol > S-aceclidine > arecoline > R-aceclidine > pilocarpine > McN-A-343
M3 Oxo-M > carbachol = arecoline > S-aceclidine > pilocarpine > R-aceclidine = McN-A-343
M4
Oxo-M > carbachol = S-aceclidine > arecoline > McN-A-343 > R-aceclidine = pilocarpine