TABLE 1

Characterization of compounds in radioligand competition binding assays using [³H]CP 55,940

Ligands	Mean K_i (nM)^*, 95% Confidence Interval of K_i Values (nM)
Ligands		hCB₂	hCB₁	hCB₂/hCB₁ Selectivity	rCB₂	rCB₁	rCB₂/rCB₁ Selectivity
A-836339	0.64	270	421	0.76	143	189
	0.46–0.90	130–590		0.42–1.3	66–310
A-796260	4.6	950	206	16	400	26
	2.2–9.6	580–1500		9.2–26	170–900
JWH-015	35	1200	34	63	770	12
	27–46	760–1900		40–97	490–120
AM1241	10	1300	125	3.4	120	36
	6.8–16	350–4500		1.6–7.3	7.7–1700
GW-842166X	2000	>10000	N.A.	2600	>10,000	N.A.
	560–7100			990–6700
L-768,242 (GW405833)	7.6	1600	210	11	N.D.	N.A.
	2.2–26	1100–2500		4.7–26

N.D., not determined; N.A., not applicable
↵* All K_i values are derived from at least three studies performed in duplicate