Compound | [3H]Flunitrazepam | [3H]Ro 15-1788 | [3H]Ro 15-4513 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Rat Cortex | α1β3*γ2S | α2β3*γ2S | α3β3*γ2S | α5β3*γ2S | α4β3*γ2S | α6β3*γ2S | |||||
NS11394 | 0.423 ± 0.083 | 0.41 ± 0.12 | 0.84 ± 0.10 | 0.497 ± 0.046 | 0.119 ± 0.029 | 324 ± 24 | 1009 ± 160 | ||||
Diazepam | 11.3 ± 3.1 | 10.1 ± 1.8 | 7.5 ± 1.4 | 19.3 ± 3.6 | 5.33 ± 0.53 | >15,000 | >15,000 |