Chronic effects of remogliflozin etabonate on physiological and metabolic parameters in db/db mice Data are presented as means ± S.E.M. (n = 6 for db/+m mice, n = 8 for db/db mice). Remogliflozin etabonate was orally administered to db/db mice twice daily for 6 weeks. These mice were fasted for 16 h every 2 weeks, and FPG, GHb, fasting plasma insulin, and fasting plasma triglyceride were monitored. After 6 weeks of administration, these mice were kept in metabolic cages to collect urine for 24 h, and UGE was then determined.
Remogliflozin Etabonate | Body Weight | Food Intake | FPG | GHb | Fasting Plasma Insulin | Fasting Plasma Triglyceride | UGE | |
|---|---|---|---|---|---|---|---|---|
| mg/kg | g | g/day | mg/dl | % | ng/ml | mg/dl | mg/body | |
| Before treatment | ||||||||
| db/+m | 22.6 ± 0.2 | 89 ± 5 | 3.8 ± 0.0 | 0.4 ± 0.1 | 62 ± 4 | |||
| db/db | 34.9 ± 0.5## | 406 ± 40## | 5.3 ± 0.1## | 6.9 ± 0.8## | 62 ± 3 | |||
| 10 mg/kg b.i.d. | 34.4 ± 0.4 | 380 ± 45 | 5.2 ± 0.1 | 6.3 ± 0.7 | 66 ± 7 | |||
| 30 mg/kg b.i.d. | 34.6 ± 0.4 | 400 ± 34 | 5.3 ± 0.1 | 6.6 ± 0.6 | 74 ± 5 | |||
| Treated for 2 weeks | ||||||||
| db/+m | 27.6 ± 0.2 | 6.4 ± 0.3 | 105 ± 6 | 3.3 ± 0.1 | 0.3 ± 0.0 | 57 ± 1 | ||
| db/db | 36.5 ± 0.8## | 7.8 ± 0.4# | 428 ± 33## | 7.4 ± 0.2## | 8.0 ± 1.1## | 78 ± 5## | ||
| 10 mg/kg b.i.d. | 36.8 ± 0.7 | 7.7 ± 0.3 | 400 ± 37 | 6.5 ± 0.1** | 8.3 ± 0.8 | 74 ± 3 | ||
| 30 mg/kg b.i.d. | 36.5 ± 0.8 | 7.1 ± 0.3 | 291 ± 32* | 6.2 ± 0.2** | 9.5 ± 1.5 | 77 ± 4 | ||
| Treated for 4 weeks | ||||||||
| db/+m | 28.9 ± 0.3 | 5.4 ± 0.3 | 105 ± 8 | 3.6 ± 0.0 | 0.2 ± 0.0 | 50 ± 1 | ||
| db/db | 36.5 ± 1.2## | 9.0 ± 0.5## | 502 ± 43## | 8.2 ± 0.3## | 5.3 ± 0.9## | 86 ± 8## | ||
| 10 mg/kg b.i.d. | 38.1 ± 0.9 | 8.5 ± 0.5 | 332 ± 31** | 7.1 ± 0.4* | 11.0 ± 2.3* | 72 ± 6 | ||
| 30 mg/kg b.i.d. | 38.9 ± 0.7 | 8.4 ± 0.5 | 255 ± 22** | 6.9 ± 0.3* | 11.1 ± 1.0* | 72 ± 5 | ||
| Treated for 6 weeks | ||||||||
| db/+m | 29.2 ± 0.3 | 4.8 ± 0.2 | 90 ± 7 | 3.3 ± 0.0 | 0.3 ± 0.1 | 44 ± 2 | 0 ± 0 | |
| db/db | 34.7 ± 1.4## | 9.1 ± 0.5## | 483 ± 22## | 8.9 ± 0.4## | 5.3 ± 1.1## | 91 ± 9## | 673 ± 82## | |
| 10 mg/kg b.i.d. | 38.1 ± 1.2 | 8.6 ± 1.1 | 307 ± 39** | 7.0 ± 0.3** | 12.0 ± 2.0* | 68 ± 4* | 197 ± 81** | |
|
| 30 mg/kg b.i.d. | 40.3 ± 0.8** | 8.5 ± 0.5 | 245 ± 29** | 6.4 ± 0.3** | 13.0 ± 2.4* | 67 ± 3* | 160 ± 84** |