TABLE 1

Ki values of remogliflozin etabonate, remogliflozin, and phlorizin for human and rat SGLTs Data are presented as means ± S.E.M. from four experiments. SGLT1 or SGLT2 expression plasmid was transfected into COS-7 cells. An AMG uptake experiment was performed using transiently transfected cells, and the Ki values for each SGLT were calculated.



Ki Value

Human SGLT1
Human SGLT2
Rat SGLT1
Rat SGLT2
nM
Remogliflozin etabonate 43100 ± 5400 1950 ± 151 8570 ± 525 2140 ± 127
Remogliflozin 4520 ± 641 12.4 ± 0.5 997 ± 73 26.0 ± 2.4
Phlorizin
227 ± 22
33.1 ± 2.2
143 ± 32
54.3 ± 3.4