Effect of JNJ-27141491 on other chemokine-chemokine receptor functional interactions Results from experiments carried out by Euroscreen using their aequorin-based calcium mobilization method for testing functional G protein-coupled receptor activity (AequoScreen, www.euroscreen.com). Results are represented as IC50 values of duplicate determinations.
Receptor | Chemokine | IC50 |
|---|---|---|
| μM | ||
| hCCR1 | MIP-1α | 0.6 |
| hCCR2 | MCP-1 | 0.04 |
| hCCR2 | MCP-3 | 0.05 |
| hCCR3 | Eotaxin | >5 |
| hCCR4 | Macrophage-derived chemokine | >5 |
| hCCR5 | Regulated on activation normal T cell expressed and secreted | ∼5 |
| hCCR6 | MIP-3α | >5 |
| hCCR7 | MIP-1β | >5 |
| hCCR8 | I-309 | ∼5 |
| hCXCR1/2 | IL-8 | >5 |
| hCXCR3 | Interferon-inducible T cell α chemoattractant | >5 |