TABLE 2

BEI and in vitro intrinsic Clbiliary of ARBs and statins in sandwich-cultured hepatocytes from WT and TR rats Data represent mean ± S.E.M. (n = 3–4 livers).


Compound

BEI

In Vitro Intrinsic Clbiliarya
WT
TR
WT
TR
% ml/min/kg
E2–17βG 18.4 ± 3.9 0.378 ± 0.378 17.8 ± 0.4 0.363 ± 0.363
Olmesartan 14.7 ± 0.5 7.05 ± 0.93 1.72 ± 0.25 0.931 ± 0.167
Valsartan 18.9 ± 2.6 1.63 ± 1.33 3.24 ± 0.51 0.406 ± 0.341
Pravastatin 43.4 ± 2.3 10.7 ± 3.4 4.43 ± 0.75 1.13 ± 0.33
Rosuvastatin 44.9 ± 6.1 20.6 ± 3.9 46.1 ± 0.4 21.2 ± 6.0
Pitavastatin
19.9 ± 1.4
6.54 ± 3.38
34.6 ± 3.1
10.4 ± 5.4
  • a In vitro intrinsic Clbiliary values were calculated according to eq. 2 based on a 10-min incubation at concentrations of 1 μM for E2–17βG and 5 μM for all other compounds