Drug | EC50 [Ke, nM] | Emax |
---|---|---|
nM ± S.D. | % ± S.D. | |
Experiment 1 (Fig. 9) | ||
d-Amphetamine | 5.8 ± 0.4 | 102 ± 2 |
+ SoRI-9804 (0.1 μM) | 7.2 ± 0.4* | 100 ± 0.8 |
+ SoRI-9804 (0.4 μM) | 8.7 ± 0.6* | 96 ± 1* |
+ SoRI-9804 (2.0 μM) | 8.3 ± 1.0* | 86 ± 2* |
+ SoRI-9804 (10 μM) | 11.5 ± 0.4* | 73 ± 0.5* |
+ cocaine (2.8 μM) | 82 ± 9* | 102 ± 2 |
Experiment 2 (Fig. 10) | ||
d-Amphetamine | 6.5 ± 0.3 | 103 ± 1 |
+ SoRI-20040 (0.1 μM) | 7.1 ± 0.4 | 100 ± 0.9 |
+ SoRI-20040 (0.4 μM) | 12.4 ± 0.9* | 93 ± 1.1* |
+ SoRI-20040 (2.0 μM) | 11.6 ± 1.5* | 78 ± 2* |
+ SoRI-20040 (10 μM) | 15.7 ± 2.5* | 60 ± 2* |
+ indatraline (66 nM) | 116 ± 14* | 101 ± 3 |
↵* p < 0.05 (Student's t test) compared with the value of the control condition.