TABLE 4

SoRI analogs partially inhibit [3H]DA uptake binding

[3H]DA uptake into striatal synaptosomes was conducted as described under Materials and Methods. Ten-point inhibition curves were generated for each test drug using 5 nM [3H]DA. The data were transformed to percentage of inhibition and fit to the dose-response curve for the best-fit estimates of the EC50 and Emax values, using KaleidaGraph version 3.6.4. All curves were generated from an n = 3. Each value is ±S.D.




EC50

Emax
nM %
GBR12909 8.8 ± 1.5 120 ± 7*
Indatraline 6.6 ± 0.6 105 ± 2
SoRI-20040 3120 ± 580 68 ± 3*
SoRI-20041 1770 ± 130 77 ± 1*
SoRI-2827
2385 ± 440
78 ± 4*
  • * p <0.05 (Student's t test) compared with indatraline.