TABLE 3

Effect of SoRI compounds on the dissociation of [125I]RTI-55 from hDAT

Dissociation experiments were conducted as described in Table 2 and under Materials and Methods. Each parameter is ±S.D.


Condition

One-Component Fit, K-1

Two-Component Fit
min-1
A. SoRI-20040
    RTI-55 0.055 ± 0.002
    SoRI-20040 A1 = 57 ± 35
K-1 = 0.059 ± 0.036
A2 = 41 ± 36
K-2 = 0.0047 ± 0.013
    RTI-55 + SoRI-20040 0.038 ± 0.001*
B. SoRI-20041
    RTI-55 0.066 ± 0.003
    SoRI-20041 A1 = 51 ± 17
K-1 = 0.063 ± 0.026
A2 = 46 ± 18
K-2 = 0 ± 0.006
    RTI-55 + SoRI-20041 0.038 ± 0.001*
C. SoRI-2827
    RTI-55 0.048 ± 0.001
    SoRI-2827 A1 = 67 ± 19
K-1 = 0.064 ± 0.022
A2 = 36 ± 20
K-2 = 0 ± 0.008
    RTI-55 + SoRI-2827
0.044 ± 0.001

  • * p < 0.05 (Student's t test) compared with the RTI-55 condition.