TABLE 1

Intrinsic blocking activity and recovery of epithelial sodium channel blockers on sodium-dependent Isc using primary canine and human bronchial epithelial cells

All values are the mean ± S.D; the number in parentheses represents the number of observations.


Compound

CBE

HBE
IC50a
Recovery
IC50a
Recovery
nM % nM %
Amilorideb 781 ± 331 (40) 90.0 ± 27.5 (39) 389 ± 188 (22) 89.5 ± 10.7 (4)
552-02
7.54 ± 2.71 (461)
18.6 ± 10.4 (426)
6.40 ± 5.93 (18)
38.2 ± 22.0 (9)
  • a The IC50 value was calculated fitted to a nonlinear regression sigmoidal concentration-effect curve with no weighting.

  • b Commercially available epithelial sodium channel blocker.