TABLE 1

Total average number of arm crosses in the plus maze test during withdrawal

Assessment of total number of crosses in the plus-maze test during nicotine withdrawal. Using the precipitated model, nicotine-dependent mice were treated with mecamylamine (2 mg/kg) on test day (day 14), and the total number of crosses between open and closed arms of the plus-maze test was counted. Numbers are presented as the total average number of arm crosses ± S.E.M. for six to eight mice per group.

C57BL/6J mice	Sal-Sal	Sal-Mec	Nicotine-Sal	Nicotine-Mec
	3.7 ± 0.64	4.2 ± 0.67	3.3 ± 0.42	4.2 ± 0.51
β2 mice	Sal-WT	Sal-KO	Mec-WT	Mec-KO
	3.6 ± 0.59	3.6 ± 0.32	4 ± 0.46	3.3 ± 0.59
α7 mice	Sal-WT	Sal-KO	Mec-WT	Mec-KO
	2.7 ± 0.42	3.5 ± 0.48	3 ± 0.53	2.7 ± 0.28
α5 mice	Sal-WT	Sal-KO	Mec-WT	Mec-KO
	2.8 ± 0.51	3 ± 0.49	3.3 ± 0.42	3.2 ± 0.40