TABLE 1

Average PCKN values from rats (n = 5) for monovalent and multivalent forms of scFv6H4 determined in the presence of steady-state METH infusions

These PCKN values for scFv6H4 in serum were determined based on the serum concentrations of [3H]scFv6H4 determined by SEC and liquid scintillation spectrophotometry quantitation of the [3H]scFv6H4. See Fig. 7 for the scFv6H4 serum concentration-time data.


ScFv6H4 form

Pharmacokinetic Parameters
λz
t1/2λz
VSS
CLs
min-1 min ml/kg ml/min/kg
Monovalent 0.07 5.8 780 9.4
    S.D. 0.02 0.8 234 2.8
    CV (%) 22.9 13.7 30 29.6
Multivalent 0.0031 228 346 1.1
    S.D. 0.0004 38 33 0.2
    CV (%)
14.1
16.8
9.6
21.0