TABLE 3

Influence of S33138 in comparison to haloperidol, clozapine, olanzapine, and risperidone upon motor behavior in rats and mice

Doses are in milligrams/kilogram subcutaneously. Data are means ± S.E.M. Number is given within brackets. ANOVA is as follows. Influence upon spontaneous locomotor activity in rats, S33138, F(3,20) = 16.8, P < 0.01; haloperidol, F(4,25) = 8.1, P < 0.01; clozapine, F(5,57) = 15.6, P < 0.01; olanzapine, F(6,45) = 14.2 P < 0.01; and risperidone, F(4,36) = 21.6, P < 0.01. Influence upon spontaneous locomotor activity in mice: S33138, F(3,24) = 33.3, P < 0.01; haloperidol, F(3,50) = 63.0, P < 0.01; clozapine, F(4,29) = 37.7, P < 0.01; olanzapine, F(5,35) = 36.0, P < 0.01; and risperidone, F(3,20) = 36.1, P < 0.01. Rotarod procedure in mice: S33138, F(3,20) = 10.7, P < 0.01; haloperidol, F(5,56) = 18.2, P < 0.01; clozapine, F(5,42) = 9.6, P < 0.01; olanzapine, F(5,48) = 7.7, P < 0.01; and risperidone, F(5,41) = 14.7, P < 0.01.


Drug

Dose

Spontaneous Locomotion

Rotarod
Rats
Mice
Mice
counts counts latency to fall (s)
S33138 0 54.6 ± 7.5 (7) 323 ± 25 (8) 263 ± 38 (6)
0.63 43 ± 10.2 (4) 274 ± 23 (5) 257 ± 39 (5)
2.5 8.4 ± 2.7 (5)* 108 ± 21 (7)* 120 ± 14 (5)*
10.0 1.6 ± 0.7 (5)* 53 ± 12 (5)* 65 ± 15 (5)*
Haloperidol 0 58.9 ± 8.4 (15) 320 ± 15 (20) 259 ± 17 (22)
0.01 49.4 ± 7.3 (7)
0.02 35.6 ± 6.9 (7)*
0.04 22.4 ± 6.5 (7)* 268 ± 24 (9) 252 ± 41 (6)
0.08 100 ± 25 (7)*
0.16 5.9 ± 1.7* 163 ± 14 (9)* 103 ± 19 (7)*
0.63 91 ± 12 (13)* 87 ± 23 (8)*
2.5 37 ± 7 (7)*
Clozapine 0 54 ± 4.8 (19) 302 ± 19 (8) 282 ± 24 (11)
0.16 284 ± 30 (5) 253 ± 51 (6)
0.63 177 ± 31 (5)* 201 ± 54 (7)
2.5 41.4 ± 7.3 (8) 59.8 ± 15.9 (6)* 155 ± 50 (7)*
5.0 17.2 ± 6.4 (10)* 23 ± 10 (6)*
10.0 14.5 ± 1.8 (8)* 26.5 ± (6)* 3 ± 1 (6)*
40.0 10.5 ± 1.5 (8)*
80.0 5.8 ± 2.3 (5)*
Olanzapine 0 54.2 ± 5.5 (13) 370 ± 27 (7) 267 ± 21 (9)
0.01 50 ± 9.0 (5)
0.04 48.5 ± 6.5 (6) 332 ± 32 (6) 260 ± 41 (6)
0.16 38.5 ± 4.2 (6)* 261 ± 40 (6)* 159 ± 26 (12)*
0.63 15.8 ± 3.2 (6)* 102 ± 12 (6)* 150 ± 33 (12)*
2.5 6.7 ± 1.5 (6)* 35 ± 12 (6)* 92 ± 38 (5)*
10.0 2 ± 0.9 (4)* 16 ± 10 (5)* 4 ± 1 (5)*
Risperidone 0 53.9 ± 5.0 (14) 289 ± 23.8 (6) 266 ± 32 (9)
0.04 32.2 ± 6.7 (5)* 237 ± 33 (5) 195 ± 33 (5)
0.16 21.8 ± 5.6 (5)* 46.4 ± 17.6 (5)* 132 ± 25 (8)*
0.63 10.2 ± 2.5 (5)* 18.4 ± 8 (5)* 88 ± 36 (6)*
2.5 1.9 ± 1.0 (8)* 38 ± 10 (9)*

10.0


3 ± 1 (5)*
  • * P < 0.05, significance of differences to vehicle values in Dunnett's test following ANOVA.