Influence of S33138 in comparison to haloperidol, clozapine, olanzapine, and risperidone upon motor behavior in rats and mice
Doses are in milligrams/kilogram subcutaneously. Data are means ± S.E.M. Number is given within brackets. ANOVA is as follows. Influence upon spontaneous locomotor activity in rats, S33138, F(3,20) = 16.8, P < 0.01; haloperidol, F(4,25) = 8.1, P < 0.01; clozapine, F(5,57) = 15.6, P < 0.01; olanzapine, F(6,45) = 14.2 P < 0.01; and risperidone, F(4,36) = 21.6, P < 0.01. Influence upon spontaneous locomotor activity in mice: S33138, F(3,24) = 33.3, P < 0.01; haloperidol, F(3,50) = 63.0, P < 0.01; clozapine, F(4,29) = 37.7, P < 0.01; olanzapine, F(5,35) = 36.0, P < 0.01; and risperidone, F(3,20) = 36.1, P < 0.01. Rotarod procedure in mice: S33138, F(3,20) = 10.7, P < 0.01; haloperidol, F(5,56) = 18.2, P < 0.01; clozapine, F(5,42) = 9.6, P < 0.01; olanzapine, F(5,48) = 7.7, P < 0.01; and risperidone, F(5,41) = 14.7, P < 0.01.
Drug | Dose | Spontaneous Locomotion | Rotarod | ||
|---|---|---|---|---|---|
| Rats | Mice | Mice | |||
| counts | counts | latency to fall (s) | |||
| S33138 | 0 | 54.6 ± 7.5 (7) | 323 ± 25 (8) | 263 ± 38 (6) | |
| 0.63 | 43 ± 10.2 (4) | 274 ± 23 (5) | 257 ± 39 (5) | ||
| 2.5 | 8.4 ± 2.7 (5)* | 108 ± 21 (7)* | 120 ± 14 (5)* | ||
| 10.0 | 1.6 ± 0.7 (5)* | 53 ± 12 (5)* | 65 ± 15 (5)* | ||
| Haloperidol | 0 | 58.9 ± 8.4 (15) | 320 ± 15 (20) | 259 ± 17 (22) | |
| 0.01 | 49.4 ± 7.3 (7) | ||||
| 0.02 | 35.6 ± 6.9 (7)* | ||||
| 0.04 | 22.4 ± 6.5 (7)* | 268 ± 24 (9) | 252 ± 41 (6) | ||
| 0.08 | 100 ± 25 (7)* | ||||
| 0.16 | 5.9 ± 1.7* | 163 ± 14 (9)* | 103 ± 19 (7)* | ||
| 0.63 | 91 ± 12 (13)* | 87 ± 23 (8)* | |||
| 2.5 | 37 ± 7 (7)* | ||||
| Clozapine | 0 | 54 ± 4.8 (19) | 302 ± 19 (8) | 282 ± 24 (11) | |
| 0.16 | 284 ± 30 (5) | 253 ± 51 (6) | |||
| 0.63 | 177 ± 31 (5)* | 201 ± 54 (7) | |||
| 2.5 | 41.4 ± 7.3 (8) | 59.8 ± 15.9 (6)* | 155 ± 50 (7)* | ||
| 5.0 | 17.2 ± 6.4 (10)* | 23 ± 10 (6)* | |||
| 10.0 | 14.5 ± 1.8 (8)* | 26.5 ± (6)* | 3 ± 1 (6)* | ||
| 40.0 | 10.5 ± 1.5 (8)* | ||||
| 80.0 | 5.8 ± 2.3 (5)* | ||||
| Olanzapine | 0 | 54.2 ± 5.5 (13) | 370 ± 27 (7) | 267 ± 21 (9) | |
| 0.01 | 50 ± 9.0 (5) | ||||
| 0.04 | 48.5 ± 6.5 (6) | 332 ± 32 (6) | 260 ± 41 (6) | ||
| 0.16 | 38.5 ± 4.2 (6)* | 261 ± 40 (6)* | 159 ± 26 (12)* | ||
| 0.63 | 15.8 ± 3.2 (6)* | 102 ± 12 (6)* | 150 ± 33 (12)* | ||
| 2.5 | 6.7 ± 1.5 (6)* | 35 ± 12 (6)* | 92 ± 38 (5)* | ||
| 10.0 | 2 ± 0.9 (4)* | 16 ± 10 (5)* | 4 ± 1 (5)* | ||
| Risperidone | 0 | 53.9 ± 5.0 (14) | 289 ± 23.8 (6) | 266 ± 32 (9) | |
| 0.04 | 32.2 ± 6.7 (5)* | 237 ± 33 (5) | 195 ± 33 (5) | ||
| 0.16 | 21.8 ± 5.6 (5)* | 46.4 ± 17.6 (5)* | 132 ± 25 (8)* | ||
| 0.63 | 10.2 ± 2.5 (5)* | 18.4 ± 8 (5)* | 88 ± 36 (6)* | ||
| 2.5 | 1.9 ± 1.0 (8)* | 38 ± 10 (9)* | |||
|
| 10.0 |
|
| 3 ± 1 (5)* | |
↵* P < 0.05, significance of differences to vehicle values in Dunnett's test following ANOVA.