TABLE 2

Influence of S33138 in comparison to haloperidol, clozapine, olanzapine, and risperidone upon performance in the five-choice serial reaction time test in rats

Data are means ± S.E.M. n = 7-11 per value. ANOVA is as follows. Percentage of correct responses: S33138, F(3,39) = 0.5, P > 0.05; haloperidol, F(3,34) = 1.5, P > 0.05; clozapine, F(3,32) = 6.8, P < 0.01; olanzapine, F(3,32) = 6.4, P < 0.01; and risperidone, F(3,38) = 3.6, P < 0.05. Anticipatory responses: S33138, F(3,39) = 1.1, P > 0.05; haloperidol, F(3,34) = 10.4, P < 0.01; clozapine, F(3,32) = 0.8, P > 0.05; olanzapine, F(3,32) = 1.3, P > 0.05; and risperidone, F (3,38) = 5.6, P < 0.01. Omissions: S33138, F(3,39) = 6.7, P < 0.01; haloperidol, F(3,34) = 56.0, P < 0.01; clozapine, F(3,32) = 11.6, P < 0.01); olanzapine, F(3,32) = 14.0, P < 0.01; and risperidone, F(3,38) = 18.4, P < 0.01.

Drug
Dose
% Correct Responses
Anticipatory Responses
Omissions
mg/kg s.c.
S33138 0 62.2 ± 2.2 13.4 ± 1.5 9.4 ± 2.0
0.04 62.9 ± 5.1 16.6 ± 3.7 5.5 ± 1.1
0.63 60.3 ± 4.0 13.1 ± 3.8 9.0 ± 2.2
2.5 57.0 ± 3.7 9.3 ± 2.1 35.1 ± 12.1*
Haloperidol 0 67.7 ± 2.5 6.4 ± 1.4 6.9 ± 1.1
0.01 69.5 ± 2.7 7.1 ± 1.1 5.9 ± 1.9
0.04 61.5 ± 3.5 13.1 ± 2.2* 39.4 ± 9.2*
0.16 53.0 ± 11.8 1.3 ± 0.4 88.7 ± 3.2*
Clozapine 0 67.5 ± 2.7 11.4 ± 2.7 9.6 ± 2.8
0.16 68.7 ± 3.1 10.5 ± 2.5 8.6 ± 1.5
0.63 58.8 ± 3.4 13.2 ± 1.9 10.3 ± 3.3
2.5 48.7 ± 4.6* 16.2 ± 3.7 48.9 ± 10.6*
Olanzapine 0 69.8 ± 3.0 7.2 ± 2.1 8.6 ± 1.8
0.04 67.4 ± 2.2 12.5 ± 3.4 7.6 ± 2.8
0.16 67.1 ± 2.9 7.7 ± 1.8 11.6 ± 3.4
0.63 55.9 ± 2.0* 13.0 ± 2.9 39.8 ± 6.4*
Risperidone 0 67.4 ± 3.8 5.9 ± 0.6 5.6 ± 1.2
0.04 67.5 ± 3.0 8.4 ± 1.2 10.3 ± 1.6
0.16 59.4 ± 3.2 17.2 ± 3.2* 28.0 ± 4.4*
0.63
54.1 ± 3.9*
10.4 ± 1.8
48.5 ± 6.8*

  • ↵* P < 0.05, significance of differences to vehicle values in Dunnett's test following ANOVA.