Region | Vehicle | 10 | 10–20-30 | 10–30-60 |
---|---|---|---|---|
mg / kg THC | ||||
Hippocampus | ||||
Emax (% stimulation) | 94 ± 5.4 | 69 ± 4.6a | 67 ± 4.6b | 58 ± 7.4b |
EC50 (nM) | 7.5 ± 1.3 | 17 ± 4.2 | 14 ± 0.9 | 26 ± 7.1a |
Basal (fmol/mg) | 167 ± 33 | 158 ± 28 | 189 ± 35 | 170 ± 34 |
Striatum/GP | ||||
Emax (% stimulation) | 70 ± 3.1 | 72 ± 7.4 | 52 ± 4.4a | 43 ± 1.2b |
EC50 (nM) | 32 ± 6.6 | 24 ± 3.2 | 49 ± 24 | 38 ± 6.3 |
Basal (fmol/mg) | 336 ± 58 | 170 ± 22a | 250 ± 35 | 170 ± 14a |
Cerebellum | ||||
Emax (% stimulation) | 255 ± 21 | 210 ± 7.8 | 202 ± 17 | 189 ± 16a |
EC50 (nM) | 26 ± 9.2 | 56 ± 15 | 28 ± 11 | 43 ± 18 |
Basal (fmol/mg) | 106 ± 20 | 100 ± 11 | 88 ± 4.5 | 91 ± 8.6 |