TABLE 3

Effect of dexamethasone and/or calcitriol on the immune response of established TNBS colitis

TNBS-treated mice were treated i.p. with dexamethasone and/or calcitriol from days 3 to 5. MPO activity, TNFα, and IL-12p70 were determined on day 5. The results are the mean ± S.E.M. from eight mice per group.




MPO Activity

TNFα

IL-12p70
U/g colon tissue pg/mg protein
Control 0.23 ± 0.18 3.17 ± 0.47 3.83 ± 0.20
TNBS 17.38 ± 1.20 16.77 ± 0.91 19.26 ± 0.75
Calcitriol (0.2 μg/kg) 10.58 ± 0.57a 9.61 ± 0.96a 13.72 ± 0.97b
Dex (0.6 mg/kg) 8.84 ± 0.49a 8.54 ± 0.64a 10.50 ± 0.52a
Dex (0.6 mg/kg) + calcitriol (0.2 μg/kg)
3.65 ± 0.89a
5.03 ± 0.73a
7.04 ± 0.72a
  • a P < 0.001 vs. TNBS-treated mice.

  • b P < 0.01 vs. TNBS-treated mice.