TABLE 2

Effect of dexamethasone and/or calcitriol on clinical parameters of acute TNBS colitis

TNBS-treated mice were treated i.p. with dexamethasone and/or calcitriol. BW change on day 3 in percentage of day 0, clinical activity score (CAS), colon length, and colon weight (distal 6 cm) were determined on day 3 as described in detail under Materials and Methods. Data represent mean ± S.E.M. from three separate experiments (eight mice per group per experiment).




Δ BW

CAS

Colon Length

Colon Weight
% cm mg
Control 0.55 ± 0.34 0.45 ± 0.17 12.94 ± 0.16 150.29 ± 7.48
TNBS -16.11 ± 1.60 11.50 ± 0.67 9.93 ± 0.15 327.41 ± 7.85
Calcitriol (0.2 μg/kg) -14.42 ± 1.71a 7.86 ± 0.86b 11.00 ± 0.18b 258.43 ± 11.96c
Dex (0.6 mg/kg) -10.60 ± 2.07a 7.00 ± 1.02c 10.91 ± 0.28b 245.33 ± 7.17c
Dex (0.6 mg/kg) + calcitriol (0.2 μg/kg) -7.38 ± 1.22c 5.00 ± 0.60c 11.32 ± 0.30c 210.75 ± 9.40c
Dex (0.9 mg/kg) -9.20 ± 1.99a 6.11 ± 0.48c 11.10 ± 0.39b 228.44 ± 8.08c
Dex (0.9 mg/kg) + calcitriol (0.2 μg/kg) -5.72 ± 0.66c 2.45 ± 0.31c 11.95 ± 0.21c 171.55 ± 5.61c
Dex (1.2 mg/kg) -6.80 ± 0.82c 2.88 ± 0.35c 12.00 ± 0.22c 179.75 ± 8.98c
Dex (1.2 mg/kg) + calcitriol (0.2 μg/kg)
-5.05 ± 1.07c
1.90 ± 0.75c
12.14 ± 0.24c
166.56 ± 7.37c
  • a P < 0.05 vs. TNBS-treated mice.

  • b P < 0.01 vs. TNBS-treated mice.

  • c P < 0.001 vs. TNBS-treated mice.