Pharmacology of TREK-1 K+ channel inhibition
Drug | IC50 | Source |
|---|---|---|
| μM | ||
| Penfluridol | 0.187,0.350 | Gomora and Enyeart (1999a), Enyeart et al. (2002a) |
| Fluspirilene | 0.232 | Gomora and Enyeart (1999a) |
| Pimozide | 0.354 | Gomora and Enyeart (1999a) |
| Amlodipine | 0.43 | This study |
| Mibefradil | 0.500 | Gomora and Enyeart (1999b) |
| Niguldipine | 0.75 | This study |
| Flupenthixol | 2.0 | Thümmler et al. (2007) |
| Flunarizine | 2.48 | This study |
| Chlorpromazine | 2.70 | Meadows et al. (2001) |
| Sipatrigine | 4.0 | Meadows et al. (2001) |
| Fluphenazine | 4.7 | Thümmler et al. (2007) |
| Anandamide | 5.10 | This study |
| Haloperidol | 5.5 | Meadows et al. (2001) |
| Nifedipine | 8.18 | This study |
| Fluoxetine | 19.0 | Kennard et al. (2005) |
| Loxapine | 19.7 | Meadows et al. (2001) |
| Quinidine | 24.1 | Gomora and Enyeart (1999a) |
| l-cis-Diltiazem | 24.8 | Gomora and Enyeart (1999a) |
| Yb3+ | 50 | Enyeart et al. (2002b) |
| La3+ | 52 | Enyeart et al. (2002b) |
| Glibenclamide | 64 | Gomora and Enyeart (1999a) |
| Bupivacaine | 113 | Gomora and Enyeart (1999a) |
| Caffeine | 377 | Harinath and Sikdar (2005) |
| Theophylline | 486 | Harinath and Sikdar (2005) |
| Zinc | 659 | Gruss et al. (2004) |
| Tolbutamide | 784 | Gomora and Enyeart (1999a) |
| Ba2+ | 1027 | Gomora and Enyeart (1999a) |
| 4-AP | 2750 | Gomora and Enyeart (1999a) |
| TEA | 24,270 | Gomora and Enyeart (1999a) |