TABLE 3

Summary of baseline and treatment data for bladder and cardiovascular parameters in dogs treated with vehicle (n = 7) or GW427353 (1 mg/kg, n = 3; 3 mg/kg, n = 7)

Baseline values represent the mean of the last two voids before initiation of acetic acid infusion. Vehicle and GW427353 values represent the mean of three voids following infusion of acetic acid. Values are mean ± S.E.M.

	Baseline	Vehicle + Acetic Acid	Baseline	1 mg/kg GW427353 + Acetic Acid	Baseline	3 mg/kg GW427353 + Acetic Acid
Threshold volume (ml)	36 ± 8.7	26 ± 6.7	38 ± 6.3	36 ± 11	30 ± 6.1	37 ± 3.6
Voided volume (ml)	25 ± 7.9	27 ± 6.5	48 ± 17	41 ± 12	14 ± 2.2	27 ± 4.2
Voiding efficiency (%)	77 ± 13	142 ± 59	140 ± 29	116 ± 2.2	36 ± 14	34 ± 8.0
Threshold pressure (mm Hg)	45 ± 2.0^a	44 ± 14^a	20 ± 3.0	17 ± 0.7	39 ± 10	34 ± 6.1
Contraction amplitude (mm Hg)	67 ± 8.3^a	57 ± 5.2^a	36 ± 3.2	38 ± 6.8	48 ± 11	42 ± 6.8
Contraction duration (s)	40 ± 12	21 ± 3.3	55 ± 32	31 ± 3.6	36 ± 14	34 ± 8.0
MAP (mm Hg)	116 ± 10^b	113 ± 11^b	111 ± 10	87 ± 11	110 ± 6.4^b	77 ± 10^b
HR (beats/min)	137 ± 12^b	126 ± 18^b	81 ± 5.0	163 ± 14	118 ± 13^b	214 ± 25^b

↵ a Intravesical pressures in one dog not included due to a technical problem with measurement.
↵ b Cardiovascular parameters in one dog not included due to a technical problem with measurement.