The Ki values of NSAIDs for hOAT1 and hOAT3
The inhibitory effect of NSAIDs on the uptake of PAH (0.1 μM) and PCG (1 μM) by hOAT1- and hOAT3-transfected HEK293 cells, respectively, was examined. The Ki values were determined by nonlinear regression analysis. All values represent the mean ± S.D.
| Inhibitors | Ki | |
|---|---|---|
| hOAT1 | hOAT3 | |
| μM | ||
| Salicylate | 407 ± 82 | 111 ± 28 |
| Diclofenac | 1.52 ± 0.07 | 6.57 ± 0.48 |
| Sulindac | 77.8 ± 11.1 | 6.89 ± 1.51 |
| Indomethacin | 6.72 ± 1.22 | 0.979 ± 0.052 |
| Etodolac | 103 ± 23 | 12.0 ± 3.8 |
| Tolmetin | 5.08 ± 0.48 | 5.32 ± 0.53 |
| Ibuprofen | 1.38 ± 0.48 | 5.11 ± 1.13 |
| Ketoprofen | 0.890 ± 0.400 | 5.04 ± 1.5 |
| Naproxen | 1.18 ± 0.60 | 7.15 ± 2.34 |
| Phenylbutazone | 71.6 ± 7.1 | 6.82 ± 1.75 |
| Piroxicam | N.D. | 4.83 ± 1.63 |
N.D., not determined.