TABLE 4

DAMGO and DELT can interact additively or synergistically in the nucleus raphe magnus to produce antinociception

Values are the dose and 95% CL to increase paw withdrawal latency to 14 s. For the fixed dose mixtures, the values are the total dose in mass units of both drugs microinjected concurrently. Thus, for a 1:1 mixture, microinjection of 0.1 ng of DAMGO and 0.1 ng of DELT corresponds to a total dose of 0.2 ng. Theoretical additive values and estimate of the variance were calculated as described by Tallarida (2000).

Drug

ED50

95% CL
ng
DELT Alone 1318.6 (1037.5-2971.7)
DAMGO Alone 3.6 (1.9-7.7)