TABLE 1

Intraplantar injection of CFA produces thermal hyperalgesia and inflammation of the ipsilateral hindpaw

Values represent the mean ± S.E.M. Numbers of rats in each treatment group ranged from 23 to 34. RVM tissue from these rats was used in the radioreceptor and GTPγS binding experiments.


Intraplantar Treatment

Paw Withdrawal Latency

Paw Thickness
Ipsilateral
Contralateral
Ipsilateral
Contralateral
s mm
4 h
    Saline 10.0 ± 0.3 10.3 ± 0.3 5.2 ± 0.1 5.2 ± 0.1
    CFA 4.3 ± 0.2** 9.6 ± 0.4 7.2 ± 0.1** 5.1 ± 0.1
4 Days
    Saline 9.8 ± 0.3 10.1 ± 0.3 5.3 ± 0.1 5.3 ± 0.1
    CFA 4.9 ± 0.1** 9.7 ± 0.3 7.2 ± 0.1** 5.3 ± 0.1
2 Weeks
    Saline 9.9 ± 0.3 9.4 ± 0.4 5.3 ± 0.1 5.3 ± 0.1
    CFA
6.0 ± 0.2**
9.4 ± 0.3
7.6 ± 0.1**
5.3 ± 0.1
  • * p < 0.05, ** p < 0.01 compared with the corresponding hindpaw of saline-treated rats.

  • p < 0.05, p < 0.01 compared with the 4-h time point within that treatment group.