TABLE 1
Summary of nicotine potency in young and adult mice after acute injections Mice from two age groups (PND 28 and PND 75) were injected s.c. with various doses of nicotine and tested in the following responses: tail-flick test, hot-plate test, hypothermia, and locomotor activity. ED50 values (± CL) were calculated from the dose-response curve of the respective treatment, and they are expressed as milligrams per kilogram. Each dose group included 8 to 10 animals.