TABLE 2

Effect of conventional and metronomic TMZ treatment on relative mRNA expression levels of VEGF, HIF-1α, TSP-1, Ang-1, Ang-2, and Tie-2 in SF188V+ tumors (n = 7 ∼ 8)


Gene/Treatment Group

Gene Expression Median (Range)
Day 5
Day 14
Day 28
VEGF
    Control 2.18 (1.29-46.97) 14.56 (12.88-48.96) 7.98 (3.04-34.02)
    CD 13.55 (6.95-34.63) 21.32 (4.56-86.71)* 4.42 (0.78-29.91)
    MD 9.39 (2.38-65.79) 18.20 (3.34-86.19)* 3.41 (0.66-24.91)
HIF-1a
    Control 4.54 (0.44-22.07) 3.08 (0.44-5.74) 0.69 (0.48-1.44)*+
    CD 1.96 (1.08-4.31) 5.88 (1.10-12.48) 0.96 (0.27-6.41)+
    MD
2.06 (0.92-10.09)
3.94 (0.28-15.60)
0.66 (0.11-5.86)+
  • * P < 0.05 comparing with the same treatment group on day 5 using Wilcoxon rank-sum test; +P < 0.05 comparing the same treatment group on day 14 using Wilcoxon rank-sum test.