Diarrhea score in j/jAV and j+AV rats (n = 5 in each group) as determined 24 h after each daily dose of irinotecan (20 mg/kg i.p.)
Scoring criteria are given under Materials and Methods.
Group/Irinotecan Dose Number | Diarrhea Score | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | Mean Score | |||||
| j/jAV/Dose 1 | 5a | 0 | 0 | 0 | 0 | ||||
| j+AV/Dose 1 | 5 | 0 | 0 | 0 | 0 | ||||
| j/jAV/Dose 2 | 5 | 0 | 0 | 0 | 0 | ||||
| j+AV/Dose 2 | 5 | 0 | 0 | 0 | 0 | ||||
| j/jAV/Dose 3 | 0 | 0 | 1 | 4 | 2.8** | ||||
| j+AV/Dose 3 | 5 | 0 | 0 | 0 | 0 | ||||