Pain Model | ED50 | % Effect at 142 mg/kg i.p. |
---|---|---|
mg / kg i.p. | % | |
Acute nociception | ||
Rat acute thermal Inflammatory pain | >142 | 0 ± 1 |
Carrageenan | ||
Acute thermal hyperalgesia | 54 | 75 ± 5* |
Edema (Complete Freund's adjuvant) | >142 | 36 ± 7* |
Chronic thermal hyperalgesia | 38 | 59 ± 16* |
Edema Neuropathic pain | >142 | 0 ± 5 |
L5/L6 nerve ligation | 19 | 65 ± 11* (47mg/kg) |
Chronic constriction injury | 114 | 55 ± 14* |
Chemotherapy | 142 | 51 ± 6* |
↵* Significantly different (p < 0.05) from vehicle-treated animals (n = 6-12 per group).