RT Journal Article SR Electronic T1 Analysis of Histamine Receptor Knockout Mice in Models of Inflammation JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 2 OP 11 DO 10.1124/jpet.113.204214 VO 348 IS 1 A1 Detlef Neumann A1 Erich H. Schneider A1 Roland Seifert YR 2014 UL http://jpet.aspetjournals.org/content/348/1/2.abstract AB The diverse functions of histamine are mediated by four specific histamine receptor subtypes, which belong to the family of G-protein-coupled receptors. Here, we summarize data obtained with histamine-deficient l-histidine decarboxylase knockout and histamine receptor subtype knockout mice in inflammation models. Advantages and disadvantages of the knockout approaches compared with pharmacologic approaches are discussed critically. Due to many controversial data it is very difficult to draw clear-cut conclusions from the data provided in the literature. Thus, the published studies highlight the complexity of histamine function in inflammation and the need for much more systematic experimental work.