RT Journal Article
SR Electronic
T1 Endothelin-1–Induced Endoplasmic Reticulum Stress in Disease
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 163
OP 172
DO 10.1124/jpet.113.205567
VO 346
IS 2
A1 Arjun Jain
YR 2013
UL http://jpet.aspetjournals.org/content/346/2/163.abstract
AB The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a cellular stress induced by multiple stimuli and pathologic conditions. Recent evidence implicates endothelin-1 (ET-1) in the induction of placental ER stress in pregnancy disorders. ER stress has previously also been implicated in various other disease states, including neurodegenerative disorders, diabetes, and cardiovascular diseases, as has ET-1 in the pathophysiology of these conditions. However, to date, there has been no investigation of the link between ET-1 and the induction of ER stress in these disease states. Based on recent evidence and mechanistic insight into the role of ET-1 in the induction of placental ER stress, the following review attempts to outline the broader implications of ET-1–induced ER stress, as well as strategies for therapeutic intervention based around ET-1.