PT  - JOURNAL ARTICLE
AU  - Ashu Johri
AU  - M. Flint Beal
TI  - Mitochondrial Dysfunction in Neurodegenerative Diseases
AID  - 10.1124/jpet.112.192138
DP  - 2012 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 619--630
VI  - 342
IP  - 3
4099  - http://jpet.aspetjournals.org/content/342/3/619.short
4100  - http://jpet.aspetjournals.org/content/342/3/619.full
SO  - J Pharmacol Exp Ther2012 Sep 01; 342
AB  - Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, movement etc.) in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron.