RT Journal Article
SR Electronic
T1 Mitochondrial Function and Dysfunction: An Update
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 598
OP 607
DO 10.1124/jpet.112.192104
VO 342
IS 3
A1 Robert E. Davis
A1 Michael Williams
YR 2012
UL http://jpet.aspetjournals.org/content/342/3/598.abstract
AB With the current explosion of knowledge on the role of mitochondrial dysfunction in the genesis of various human disease states, there is an increased interest in targeting mitochondrial processes, pathways, and proteins for drug discovery efforts in cancer and cardiovascular, metabolic, and central nervous system diseases, the latter including autism and neurodegenerative diseases. We provide an update on understanding the central role of the mitochondrion in ATP and reactive oxygen species production and in controlling cell death pathways.