RT Journal Article
SR Electronic
T1 THE POTENTIATING ACTION OF CERTAIN XANTHINE DERIVATIVES ON GASTRIC ACID SECRETORY RESPONSES IN THE DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 362
OP 365
VO 99
IS 3
A1 C. R. Robertson
A1 C. E. Rosiere
A1 D. Blickenstaff
A1 M. I. Grossman
YR 1950
UL http://jpet.aspetjournals.org/content/99/3/362.abstract
AB Previous studies had shown that caffeine when given alone does not stimulate gastric acid secretion in the dog but does in the cat and man. The present study shows that theophylline given alone does not stimulate gastric secretion in the dog. It is demonstrated, however, that caffeine, theophylline, theobromine and xanthine increase or potentiate the effect of histamine on gastric secretion in dogs with pouches of the entire stomach. Caffeine also potentiates the gastric secretory stimulation produced by Urecholine (a parasympathomimetic drug) in dogs with pouches of the entire stomach and greatly increases the secretory response to a meal of horse meat in Heidenhain pouch dogs. The possible mechanisms of these effects are discussed.