PT  - JOURNAL ARTICLE
AU  - A. FARAH
AU  - T. C. WEST
AU  - R. ANGEL
TI  - THE ACTION OF SODIUM FLUOROACETATE ON INTESTINAL SMOOTH MUSCLE
DP  - 1950 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 234--244
VI  - 98
IP  - 3
4099  - http://jpet.aspetjournals.org/content/98/3/234.short
4100  - http://jpet.aspetjournals.org/content/98/3/234.full
SO  - J Pharmacol Exp Ther1950 Mar 01; 98
AB  - Sodium fluoroacetate inhibits the spontaneous contractions of intestinal smooth muscle. This effect is quantitatively and qualitatively different when different types of substrate are used. Complete inhibition of spontaneous contractions does not occur in the presence of glucose or mannose. Inhibition of spontaneous contractions is complete in the presence of acetate, pyruvate, oxalacetate, acetoacetic acid and a number of fatty acids as substrates. Strips of the large intestine are more resistant to NaFAc than those of the small intestine. The fluoroacetate resistant contractions occurring in the presence of glucose are abolished by iodoacetate, p-chloromercuribenzoate, dinitrophenol and sodium azide. They are not abolished by anaerobiosis, sodium cyanide, malonic and propionic acid. Under aerobic conditions and in the presence of substrate the effects of NaFAc are not reversed by repeated washing with Tyrode solution. 1950 by The American Society for Pharmacology and Experimental Therapeutics