RT Journal Article
SR Electronic
T1 THE ACTION OF N,N-DIBENZYL-BETA-CHLOROETHYLAMINE (DIBENAMINE) IN HYPERTENSIVE DOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 215
OP 223
VO 90
IS 3
A1 M. WILBURNE
A1 L. N. KATZ
A1 S. RODBARD
A1 A. SURTSHIN
YR 1947
UL http://jpet.aspetjournals.org/content/90/3/215.abstract
AB 1. The intravenous administration of a single dose of the sympatholytic agent, N,N-dibenzyl-beta-chloroethylamine (Dibenamine), to both Goldblatt hypertensive and normotensive dogs induced in 5 of 7 animals a reduction in blood pressure of approximately one hour to 2 days duration sometimes with widely fluctuating pressure levels. Administration of the drug for a period of three weeks caused no maintained reduction in arterial pressure in hypertensive dogs. 2. The inhibition of the pressor phase of epinephrine action, with the appearance of its depressor action was demonstrated within two hours following the injection of dibenamine. This inhibitory action was mainly dissipated in 24 hours. 3. Dibenamine tended to inhibit the occurrence of epinephrine-induced ventricular tachycardia. 1946 by The American Society for Pharmacology and Experimental Therapeutics