PT - JOURNAL ARTICLE AU - W. K. LONG AU - A. FARAH TI - THE INFLUENCE OF CERTAIN SULFHYDRYL COMPOUNDS ON THE TOXICITY OF AN ORGANIC MERCURIAL DIURETIC DP - 1946 Dec 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 388--399 VI - 88 IP - 4 4099 - http://jpet.aspetjournals.org/content/88/4/388.short 4100 - http://jpet.aspetjournals.org/content/88/4/388.full SO - J Pharmacol Exp Ther1946 Dec 01; 88 AB - The organic mercurial compound used in this study produced toxic manifestations which were referable mainly to the heart when it was given intravenously to animals in large enough dosage. These effects were counteracted by the intravenous injection of the sulfhydryl compounds cysteine hydrochloride, glutathione, and 2,3,-dimercaptopropanol. In the heart-lung preparation of the dog, the protective action of the three sulfhydryl compounds studied was about equal when calculated in terms of —SH equivalents, while in the intact dog, 2,3,-dimercaptopropanol was about 5 to 8 times as effective as either cysteine hydrochloride or glutathione. Cystine and methionine had a slight protective action against the organic mercury compound in mice, but none in the intact dog or in the heart-lung preparation of the dog. Cysteine hydrochloride, glutathione, and 2,3,-dimercaptopropanol did not improve either spontaneous or sodium pentobarbital cardiac failure in the dog heart-lung preparation. 1946 by The American Society for Pharmacology and Experimental Therapeutics