%0 Journal Article %A E. G. GROSS %A R. M. FEATHERSTONE %T STUDIES WITH TETRAZOLE DERIVATIVES %B III. Some Pharmacologic Properties of Amino Tetrazoles %D 1946 %J Journal of Pharmacology and Experimental Therapeutics %P 353-358 %V 88 %N 4 %X The action of a group of substituted aminotetrazole derivatives on the central nervous system has been studied. The convulsant activity and the respiratory depression of the compounds appeared to be parallel. The lack of analeptic action can be ascribed to the presence of the amino group. Certain relationships between chemical structure and pharmacologic action have become apparent. The optimum structural factors for maximum central nervous stimulation appear to be the presence of a relatively large alkyl or phenylalkyl group in position 1 and a small group, such as ethyl, on the amino group in the 5 position. Some of these compounds are stimulatory in action but their lack of analeptic activity does not suggest further investigation as useful arousal agents. 1946 by The American Society for Pharmacology and Experimental Therapeutics %U https://jpet.aspetjournals.org/content/jpet/88/4/353.full.pdf