RT Journal Article
SR Electronic
T1 STUDIES ON DDT (2,2 BIS-PARACHLORO PHENYL-1,1,1, TRICHLORETHANE): EFFECTS ON OXIDATIVE METABOLISM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 327
OP 332
VO 88
IS 4
A1 RIKER, WALTER F.
A1 HUEBNER, VIRGINIA R.
A1 RASKA, SIGWIN B.
A1 CATTELL, McKEEN
YR 1946
UL http://jpet.aspetjournals.org/content/88/4/327.abstract
AB 1. In rats poisoned with DDT there is an increase in the total metabolic rate. 2. The increased metabolic rate is reflected in an increase in food and water intake and a slight loss in body weight. 3. The oxygen uptake of liver slices from DDT poisoned rats is increased. 4. In advanced DDT poisoning, slices taken from parts of the liver showing gross abnormalities have instead of an increased oxygen uptake a reduction below the control values. 5. The oxygen consumption of sartorius muscles from frogs poisoned with DDT is increased. 6. A significant increase in the respiration of the brain tissue has not been demonstrated. 7. A known metabolite of DDT, di(p-chlorophenyl) acetic acid has been shown not to be responsible for the characteristic actions of DDT. 1946 by The American Society for Pharmacology and Experimental Therapeutics