RT Journal Article
SR Electronic
T1 STUDIES ON ANTIMALARIAL DRUGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 349
OP 356
VO 82
IS 3
A1 FRANCES K. OLDHAM
A1 F. E. KELSEY
A1 WILLIAM CANTRELL
A1 E. M. K. GEILING
YR 1944
UL http://jpet.aspetjournals.org/content/82/3/349.abstract
AB The distribution of quinine after intravenous administration in the tissues of birds infected with Plasmodium gallinaceum and of birds made anemic by bleeding or by injection of phenylhydrazine has been studied. In infected birds, the quinine concentration in the spleen, plasma, red cells, bone marrow and liver was frequently higher than in uninfected controls. Higher values were also occasionally found in the brain, leg muscle and lung. No significant differences were noted in the spinal cord, pancreas, kidney and heart. The increased quinine concentration in infected birds is probably not associated with the presence of parasites in red cells or as exo-erythrocytic stages. Relatively high quinine concentrations were found in both plasma and red cells in most of the anemic birds, and in the liver and spleen of birds made anemic with phenylhydrazine. The relationship between the anemia of the malaria infections and the fate of the injected quinine is discussed.