RT Journal Article
SR Electronic
T1 THE ENHANCEMENT OF THE PHYSIOLOGICAL ECONOMY OF PENICILLIN IN DOGS BY THE SIMULTANEOUS ADMINISTRATION OF PARA-AMINOHIPPURIC ACID II
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 310
OP 323
VO 82
IS 3
A1 KARL H. BEYER
A1 LAWRENCE PETERS
A1 ROLAND WOODWARD
A1 W. F. VERWEY
YR 1944
UL http://jpet.aspetjournals.org/content/82/3/310.abstract
AB It has been found that the continuous infusion of sodium p-aminohippurate facilitates a physiological economy by the body of single intravenous injections of penicillin. When compared with similar experiments, wherein penicillin but no p-aminohippuric acid was injected, the effectiveness of the latter agent may be judged by: 1) the prolonged maintenance of a determinable plasma concentration of penicillin, 2) a marked prolongation of the period of time over which penicillin was excreted, 3) a definite descrease in the rate of excretion of penicillin, and 4) a marked decrease in the amount of penicillin recovered in the urine in a given period of time. It was concluded that the manner in which this effect has been produced was by a competition between p-aminohippuric acid and penicillin for excretion by the renal tubular epithelium. This appeared to be the case, since the renal clearance of penicillin, which normally approximates the renal plasma flow of dogs, can be depressed to or below that measuring glomerular filtration rate by the simultaneous administration of sodium p-aminohippurate intravenously to maintain a plasma concentration that causes its own clearance to be less than maximal.