PT  - JOURNAL ARTICLE
AU  - KARL H. BEYER
AU  - LAWRENCE PETERS
AU  - ELIZABETH A. PATCH
AU  - HORACE F. RUSSO
TI  - THE RENAL ELIMINATION OF SULFAMERAZINE, SULFAMETHAZINE, SULFADIAZINE AND SULFATHIAZOLE BY THE DOG
DP  - 1944 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 239--246
VI  - 82
IP  - 3
4099  - http://jpet.aspetjournals.org/content/82/3/239.short
4100  - http://jpet.aspetjournals.org/content/82/3/239.full
SO  - J Pharmacol Exp Ther1944 Nov 01; 82
AB  - The average renal clearance values, corrected for plasma binding, for the four unconjugated sulfonamides were sulfamethazine (7.1, av.), sulfamerazine (9.3, av.), sulfadiazine (15.8, av.) and sulfathiazole (35.4, av.). The administration of sodium bicarbonate increased the urinary pH but at the same time increased the clearances of all of the compounds by interfering with their reabsorption. This effect was most striking in the case of sulfathiazole where reabsorption of the compound by the renal tubules was almost completely inhibited. The production of a water diuresis increased the clearance of each of the compounds but not quite to so great an extent as followed the administration of sodium bicarbonate. As the plasma level of the sulfonamide was raised through the ordinary therapeutic range, there was a progressive increase in the tubular reabsorption of the compounds with the result that the clearance values did not tend to change with the plasma level.