RT Journal Article
SR Electronic
T1 SOME CIRCULATORY EFFECTS OF PRIVINE HYDROCHLORIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 42
OP 47
VO 82
IS 1
A1 EMERSON, GEORGE A.
YR 1944
UL http://jpet.aspetjournals.org/content/82/1/42.abstract
AB Circulatory effects of privine HCl on intravenous injection are compared with those of some sympathomimetic amines. In dogs narcotized with pentobarbital, the minimal pressor dose is 1-2 x 10–5 mM./kg., while a maximum response is usually obtained with 5 x 10–5 to 10–4 mM./kg. Above this dose, privine generally causes cardiac irregularities which limit the pressor response. Tachyphylaxis occurs at about this dose. Atropine and cocaine do not appreciably influence the action of privine; 933F reduces but does not reverse the pressor action. Small doses of privine potentiate epinephrine but large doses are adrenolytic. Cheynes-Stokes' respiration often follows injection of large doses.