RT Journal Article SR Electronic T1 THE OXIDATION IN VITRO OF MORPHINE BY RAT LIVER SLICES JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 374 OP 377 VO 81 IS 4 A1 BERNHEIM, FREDERICK A1 BERNHEIM, MARY L. C. YR 1944 UL http://jpet.aspetjournals.org/content/81/4/374.abstract AB 1. Morphine added to rat liver slices is oxidized apparently at the hydroxy groups. Kidney and brain are inactive. 2. The reaction does not occur under anaerobic conditions or after boiling the slices. Liver cell suspensions oxidize morphine much more slowly than slices. 3. No evidence of conjugation was found. 4. Dilaudid is also oxidized under the same conditions. 5. Codeine and dionine apparently inhibit the oxidation of morphine.