RT Journal Article
SR Electronic
T1 IODINE IN BLOOD AND THYROID
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 331
OP 339
VO 81
IS 4
A1 T. S. SAPPINGTON
A1 N. HALPERIN
A1 W. T. SALTER
YR 1944
UL http://jpet.aspetjournals.org/content/81/4/331.abstract
AB Although the measurement of iodine concentration in the blood plasma is of considerable interest in connection with the use of iodine-containing drugs, the best methods now available require nearly 40 cc. of blood for duplicate analyses of blood at physiological concentrations. This fact limits the use of such methods in man, and prohibits them in small animals. The present communication describes a micro-analytical technique which will yield duplicate analyses from 2 cc. of blood plasma or serum. The method involves the catalytic effect of iodide upon the reduction of ceric ion. The technique is colorimetric and is adaptable to standard photoelectric colorimeters such as are available in many laboratories at the present time.