RT Journal Article
SR Electronic
T1 METABOLISM, TOXICITY, AND MANNER OF ACTION OF GOLD COMPOUNDS IN THE TREATMENT OF ARTHRITIS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 275
OP 278
VO 83
IS 4
A1 WALTER D. BLOCK
A1 ELIZABETH L. KNAPP
YR 1945
UL http://jpet.aspetjournals.org/content/83/4/275.abstract
AB 1. The in vitro effect of various gold-containing compounds upon the oxygen consumption of liver and kidney slices from healthy white rats was determined. 2. The oxygen consumption was inhibited by the inorganic, ionizable compounds, gold chloride and gold sodium thiosulfate, and to a lesser degree by colloidal gold sulfide. The organic, non-ionizable compounds, sodium succinimido-aurate, gold sodiumn thiomalate, and gold thioglucose, did not cause any inhibition. At equal molar concentrations of gold the degree of inhibition was greater for kidney than for liver slices. 3. Solutions of gold chloride varying in ionic concentration from M/250 to M/5000 produced the same relative degree of inhibition on the oxygen consumption of liver and kidney slices. 4. The significance of these findings in relation to earlier studies on the distribution of gold in tissues is discussed briefly.