TY - JOUR T1 - STUDIES ON THE FATE OF MORPHINE SULFURIC ETHER JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 188 LP - 192 VL - 80 IS - 2 AU - FRED W. OBERST AU - E. G. GROSS Y1 - 1944/02/01 UR - http://jpet.aspetjournals.org/content/80/2/188.abstract N2 - The excretion of morphine sulfuric ether, and in some instances its potassium salt, has been studied in 9 non-tolerant and 2 tolerant dogs, and in 2 non-addicts, 1 addict, and 10 post-addicts. It is excreted in urine as both free and bound morphine, the amounts of which are somewhat lower than that reported for morphine per se. Its pharmacological activity is of a low order; it does not produce euphoria in man or relieve pain. Neither can it be substituted for morphine in addicts nor does it relieve withdrawal symptoms. Its pain-threshold raising effect as determined by Hardy, Wolff, and Goodell technique is practically absent in man and is questionable in dogs. ER -