RT Journal Article
SR Electronic
T1 METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 31
OP 38
VO 80
IS 1
A1 VANDENBELT, J. M.
A1 PFEIFFER, CARL
A1 KAISER, MARGARET
A1 SIBERT, MARGARET
YR 1944
UL http://jpet.aspetjournals.org/content/80/1/31.abstract
AB The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.