TY - JOUR T1 - THE EFFECT OF ENVIRONMENTAL TEMPERATURE ON THE TOXICITY OF 2,4-DINITROPHENOL IN MICE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 176 LP - 178 VL - 79 IS - 2 AU - GERALDINE J. FUHRMAN AU - FRANK W. WEYMOUTH AU - JOHN FIELD, 2D Y1 - 1943/10/01 UR - http://jpet.aspetjournals.org/content/79/2/176.abstract N2 - 1. It is shown that the toxicity of 2,4-dinitrophenol in the adult albino mouse is lowered by decrease and raised by increase of environmental temperature between 6° and 40°C. 2. Calculated values of the LD50, for DNP in mgm. per kgm. were 35.7 and 30.9 at 6° and 25° respectively. The difference between these values is significant 3. The LD50 at 40°C. was not determined. However, it is shown that it lies below 8.22 mgm. DNP per kgm. and is significantly lower than the 25°C. value. ER -