TY - JOUR T1 - ENVIRONMENTAL TEMPERATURE AND DRUG ACTION IN MICE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 127 LP - 132 VL - 79 IS - 2 AU - K. K. CHEN AU - ROBERT C. ANDERSON AU - FRANK A. STELDT AU - C. A. MILLS Y1 - 1943/10/01 UR - http://jpet.aspetjournals.org/content/79/2/127.abstract N2 - 1. Of 11 drugs studied in mice at various temperatures, diamino-diphenyl sulfone given by mouth is shown to be approximately 10 times as toxic at 40°C. as at 25°C. 2. Insulin injected by vein is more than 80 times as potent at 40°C. as at 20°C. The onset of convulsions occurs sooner at high temperatures than at low ones. 3. Harmine hydrochloride administered intravenously is also increasingly toxic, although to a less degree, with the rise of temperature. It is about twice as toxic at 40°C. as at 20°C. 4. There is a suggestion that the toxicity of sulfapyridine sodium, sulfathiazole sodium, strychnine sulfate, picrotoxin, tutin, aconitine hydrobromide, and scopolamine hydrobromide, increases with the elevation of temperature— particularly at 40°C. as compared with lower temperatures. The lethal dose of sulfanilamide is least influenced by temperature. 5. Mice appear more susceptible at 40°C. to picrotoxin and tutin in developing convulsions than at 20-25°C. The speed of action is also accelerated at higher temperature levels. ER -