TY - JOUR T1 - STUDIES ON ANTIMALARIAL DRUGS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 81 LP - 84 VL - 79 IS - 1 AU - FRANCES K. OLDHAM AU - F. E. KELSEY Y1 - 1943/09/01 UR - http://jpet.aspetjournals.org/content/79/1/81.abstract N2 - The ability of rabbit liver to oxidize quinine was studied in normal animals and in animals in various stages of pregnancy. In normal animals, the enzyme is present in rather constant amounts but becomes considerably reduced during late pregnancy and during the early post-partum period. This difference appears to be due to a reduction in the amount of enzyme present rather than to the presence of an inhibitory substance. The enzyme can be demonstrated in young animals shortly after birth but is not found in amounts comparable to that of the normal adult until after the weaning period. ER -