PT  - JOURNAL ARTICLE
AU  - PAUL N. HARRIS
AU  - ROBERT C. ANDERSON
AU  - K. K. CHEN
TI  - THE ACTION OF RIDDELLINE
DP  - 1943 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 372--374
VI  - 78
IP  - 4
4099  - http://jpet.aspetjournals.org/content/78/4/372.short
4100  - http://jpet.aspetjournals.org/content/78/4/372.full
SO  - J Pharmacol Exp Ther1943 Aug 01; 78
AB  - 1. The acute toxicity of riddelline has been determined in mice by intravenous injection. 2. Like other Senecio alkaloids so far studied, riddelline produces in mice central necrosis of the liver, ascites or hydrothorax, and pulmonary edema. There is also evidence of necrosis of cortical lymphocytes in the thymus. 3. Riddelline inhibits the isolated rabbit's small intestine and stimulates the isolated guinea pig's uterus. It causes a fall of blood pressure when injected by vein in pithed or barbitalized cats.